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Diffuse large-B-cell lymphoma survival prediction genes Prediction of survival in diffuse large-B-cell lymphoma based on the expression of six genes. 6

Yagi - Pediatric AML Expression Profile Identification of a gene expression signature associated with pediatric AML prognosis. Table 2. Thirty-five genes (36 probe sets) associated with prognosis of pediatric AML 35

small B-cell lymphomas (SBCLs) 120 genes whose expression patterns differed between reactive lymph node tissue and three types of SBCL. Note : 18 genes are missing because no locus link IDs was found. 81

Regenerated mouse mdx skeletal muscle Regenerated mouse mdx skeletal muscle shows differential mRNA expression. 139 genes were identified. Few genebank accessions were associated with more than one locus link IDs, so the final list has 151 genes (note that no locus link IDs were found for 10 134

putative MLV regulatory genes. Identification of Homeodomain Proteins, PBX1 and PREP1, Involved in the Transcription of Murine Leukemia Virus. 25 putative MLV regulatory genes were identified. Note that for 10 genes (out of 25), locus link IDs couldnot be found. 15

Genes upregulated/downregulated with aging in vastus lateralis muscle Influence of aging and calorific restriction on the transcriptioal profile of skeletal muscle from rhesus monkeys. From Table 1 and 2 of PNAS 2001 98: 5093-5098 98

Caloric restriction-related increases/decreases in gene expression in neocortex of C57BL/6 mice From Table 3 and 4 of Tomás Prolla and Richard Weindruch Research Results page (Genetics Laboraory, UW-Madison). http://prolla.genetics.wisc.edu/data/aging/ 147

Aging-related increases/decreases in gene expression in neocortex of C57BL/6 mice From Table1 and 2 of Tomás Prolla and Richard Weindruch Research Results page (Genetics Laboraory, UW-Madison). http://prolla.genetics.wisc.edu/data/aging/ 145

Aging-related increases/decreases in gene expression in the cerebellum of C57BL/6 mice From Table 5 and 6 of Tomás Prolla and Richard Weindruch Research Results page (Genetics Laboraory, UW-Madison). http://prolla.genetics.wisc.edu/data/aging/ 149

Genes significantly increased in expression with age in the sedentary population Table 2 of Physiol Genomics 12: 129–138, 2003. Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart 39

Effect of aging on colonic gene expression in folate depleted rats From Table 4 of Carcinogenesis vol.25 no.1 pp.69-76, 2004. Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis 54

Effect of aging on colonic gene expression in folate Supplemented rats From Table 4 of Carcinogenesis vol.25 no.1 pp.69-76, 2004. Effects of dietary folate and aging on gene expression in the colonic mucosa of rats: implications for carcinogenesis 13

Age-related changes in gene expression in rat urinary bladder. From Table 2 of Fundamental & Clinical Pharmacology 17 (2003) 633–641 Increased adrenergic contractility and decreased mRNA expression of NOS III in aging rat urinary bladders 22

Age-regulated genes in the human frontal cortex From Table 1 of NATURE |VOL 429 | 24 JUNE 2004 Pg 883. Gene regulation and DNA damage in the ageing human brain. 142

Genes Differentially expressed in ventral prostate of old rats From Table 1 and 2 of LABORATORY INVESTIGATION Vol. 83, No. 5, p. 743, 2003 Age-Associated Changes in Histology and Gene-Expression Profile in the Rat Ventral Prostate 79

list of Downregulated ACRGs (Aging- and cognition-related genes) in rats From Table 3 of The Journal of Neuroscience, May 1, 2003 • 23(9):3807–3819-3807 Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment 65

List of Upregulated ACRGs (Aging- and cognition-related genes) in rat From Table 4 of The Journal of Neuroscience, May 1, 2003 • 23(9):3807–3819-3807 Gene Microarrays in Hippocampal Aging: Statistical Profiling Identifies Novel Processes Correlated with Cognitive Impairment 72

Changes in Gene Expression in Young Versus Elderly Human Retina From Table 2 of IOVS, August 2002, Vol. 43, No. 8, pg 2554. Microarray Analysis of Gene Expression in the Aging Human Retina 23

Genes significantly increased/decreased in expression with age in the exercised mouse population. Table 4 and 5 of Physiol Genomics 12: 129–138, 2003. Lifelong voluntary exercise in the mouse prevents age-related alterations in gene expression in the heart 32

Valk AML Prognostic Genes Table R http://content.nejm.org/cgi/content/full/350/16/1617 178

Bullinger AML See: NEJM, 4/15/04 122

Effects of Old Age on Rat Hepatic Gene Expression From Table 1 of Molecular Endocrinology 15(2): 308–318. Gene Expression Profile of the Aging Process in Rat Liver: Normalizing Effects of Growth HormoneReplacement 24

Differential gene expression in human diploid fibroblasts in Replicative Senescence From table 1 of Biochemical and Biophysical Research Communications 282, 934–939 (2001). Gene Profile of Replicative Senescence Is Different from Progeria or Elderly Donor 11

Human : Strongly downregulated genes in lenses with senile cataract From Table 1 of Downregulation of gene expression in the ageing lens: a possible contributory factor in senile cataract.Segev F, Mor O, Segev A, Belkin M, Assia EI. Eye. 2005 Jan;19(1):80-5 3

Temporal linkage between the phenotypic and genomic responses to caloric restriction (B6C3F1 mice) Late genes expressed with caloric restriction in aged mice. From Table 1 of Joseph M. Dhahbi et al. Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5524–5529. 25

Temporal linkage between the phenotypic and genomic responses to caloric restriction (B6C3F1 mice) Stable (early) genes expressed with caloric restriction in aged mice. From Table 2 of Joseph M. Dhahbi et al. Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5524–5529. 41

Temporal linkage between the phenotypic and genomic responses to caloric restriction (B6C3F1 mice) Oscillator genes expressed with caloric restriction in aged mice. From Table 3 of Joseph M. Dhahbi et al. Proc Natl Acad Sci U S A. 2004 April 13; 101(15): 5524–5529. 28

Human : Expression of Cell Differentiation Genes Altered by AGE-MG, Retinal Pigment Epithelial Cell From Table 1 of IOVS, September 2001, Vol. 42, No. 10, Induction of an Aging mRNA Retinal Pigment Epithelial Cell Phenotype by Matrix-Containing Advanced Glycation End Products In Vitro Shigeru Honda,1 Behnom Farboud,1 Leonard M 15

HUMAN: Expression of Cell Differentiation Genes Altered by AGE-MG From Table 1 of IOVS, September 2001, Vol. 42, No. 10 Induction of an Aging mRNA Retinal Pigment Epithelial Cell Phenotype by Matrix-Containing Advanced Glycation End Products In Vitro Shigeru Honda,1 Behnom Farboud,1 Leonard M. Hjelmeland,1,2 and Jame 15

Human : Genes that present age-dependent expression in normal tissues From table 2 of M. Kirschner et al. / Biochemical and Biophysical Research Communications 298 (2002) 772–778 : Oligonucleotide microarray data mining: search for age-dependent gene expression 6

Human: Genes that present age-dependent expression in tumors From table 3 of M. Kirschner et al. / Biochemical and Biophysical Research Communications 298 (2002) 772–778 : Oligonucleotide microarray data mining: search for age-dependent gene expression 11

Human : p53-controlled genes that present age-dependent expression in tumors From table 4 of M. Kirschner et al. / Biochemical and Biophysical Research Communications 298 (2002) 772–778 Oligonucleotide microarray data mining: search for age-dependent gene expression 15

A multigenic program mediating breast cancer metastasis to bone From Fig 3(c) of "A multigenic program mediating breast cancer metastasis to bone" CANCER CELL : JUNE 2003 · VOL. 3 16

Age-regulated genes in the human frontal cortex Table 1-(Yanker) gene regulation and DNA damage in the ageing human brain. Bruce A Yanker Et.Al. Nature vol. 429. 24 June 2004. PubMed ID-15190254 141

Genes Upregulated by Egr-1 in HUVEC Egr-1 target genes in human endothelial cells identified by micrarray analysis. Mingui Fu Et. Al. Gene Volume 315 pages 33-41 2003. PubMed ID: 14557062 40

4-fold or greater increase in expression in post-CPB Vs. pre-CPB/C diabetic and Nondiabetic patients Table 2:Differences in gene Expression Profiles of Diabetic and Nondiabetic Patients Undergoing Cardiopulmonary Bypass and Cardioplegic arrest. Pierre Voisine, Et. Al. 2004 J.AHA PubMedID:15364876 17

4-fold or greater increase in expression post-CPB vs. pre-CPB/C arrest atrial samples ONLY NonDiabet Differences in Gene Expression Profiles or Diabetic and Nondiabetic Patients Undergoing Cardiopulmonary Bypass and Carioplegic Arrest. Pierre Voisine Et. Al. J. Of American Heart Assoc. 2004.http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pu 17

4-fol or greater increase in expression in post-CPB vs pre-CPB/C samples ONLY Diabetic Patients Table3: Differences in Gene Expression Profiles of Diabetic Patients Undergoing cariopulmonary Bypass and cardioplegic Arrest. Pierre Voisine, et. Al. J. AHA 2004. PubMed ID: 15364876 22

Genes Downregulated by Egr-1 in HUVEC Table 2: Egr-1 target genes in human endothelial cells identified by microarray analysis. Mingui Fu, Et.Al. Gene Volume 315 pages 33-41 2003. PubMed ID: 14557062 10

Genes Typical for Macrophages Identified in LMD Analysis Table 2: Gene Expression in Macrophage-Rich Inflammatory Cell Infiltrates in Human Atherosclerotic Lesions as Studied by Laser Microdissection and DNA Array. Tuomisto Et.al Aeterioscler.Thromb.Vasc.Biol 2003. 32

Gene expression Changes in LMD Human Lesion Macrophage area Vs. Contol Areas Table 3:Gene Expression in Macrophage-Rich Inflammatory Cell Infiltrates in Human atherosclerotic Lesions. Tuomisto et.Al. Arter.Thromb.Vasc.Biol. Vol 23 2003. PMID:14576072 55

Gene Expression Changes in Blood after Stroke: PAM gene List Table 2: Gene Expression in Blood changes rapidly in neutrophils and monocytes after ischemic stroke in humans: a microarray study. Tang, Y. et al. jcbfm 2006 PubMed Id: 16395289 18

Differnetially Expressed Apoptosis-Related Genes in Atheroscl. plaques Vs. NonAtheroscl Mammary Arte Gene Expression Profiling of Apoptosis-Related Genes in Human Atherosclerosis: Upregulation of Death-Associated Protein Kinase. Martinet, w. et al. Arterioscl.thromb.vasc.Biol. JAHA Vol:22 2002. PubMed Id:12482829 17

Table 1 and Table 2:Atherosclerotic Plaque Smooth Muscle Cells Have a Distinct Phenotype Are plaque smooth muscles cells (SMCs) genetically distinct from medial SMCs as reflected by the ability to maintain a distinctive expression phenotype in vitro? Eileen R. Mulvihill, et.al; Arterioscler Thromb Vasc Biol. 2004 Vol:24; 34

Table 1:genes that showed significant difference between the arthritic and control rat blood Identification of blood biomarkers of rheumatoid arthritis by transcript profiling of peripheral blood mononuclear cells from the rat collagen-induced arthritis model; Jianyong Shou, et.al;Arthritis Research & Therapy 2006, PMID:16507131 24

TABLE 2. MICROARRAY RESULTS REVEAL MODULATION OF GENE EXPRESSION Global gene profiling reveals novel glucocorticoid induced changes in gene expression of human lens epithelial cells;Vanita Gupta, et.al;Molecular Vision 2005; 11:1018-40 PMID:16319822 221

Table 1 List of Top 89 Probe Sets Upregulated by Carbon Black (CB) Identified on U133 Chips Mechanisms Underlying Nano-Sized Air-Pollution- Mediated Progression of Atherosclerosis Carbon Black Causes Cytotoxic Injury/Inflammation and Inhibits Cell Growth in Vascular Endothelial Cells;Hideyuki Yamawaki, PhD;Naoharu Iwai, MD 89


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